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ea0008p47 | Endocrine Tumours and Neoplasia | SFE2004

Elevated FP receptor signalling in endometrial adenocarcinoma cells promotes expression of inflammatory and angiogenic genes via the EGFR and ERK1/2 pathways

List T , Boddy SC , Sales KJ , Jabbour HN

Prostaglandin F2a (PGF) is biosynthesised by cyclooxygenase (COX) enzymes and mediates its activity following FP receptor activation. Recently, we have shown elevated FP receptor expression and signalling in endometrial adenocarcinomas. This study investigated FP receptor signalling in human endometrial adenocarcinoma (Ishikawa) cells.Ishikawa cells were stably transfected with FP receptor cDNA in the sense (FPS) and antisense (FPAS) orientati...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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